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S only when covalently bound to specific subunits of the pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoacid dehydrogenase, and acetoin dehydrogenase enzyme complexes. Lipoic acid attachment is likewise required for the glycine cleavage system (called glycine decarboxylase in plants), an enzyme complex that catalyzes reactions very different from those of th
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