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S this effect by blocking dephosphorylation of serines 120 and 123 [63,64]. However, SV40 tAg appears to stimulate SV40 replication to a limited extent in vivo; SV40 tAg deletion mutants produce slightly lower numbers of virions per infected cell [43] and addition of tAg protein to cells infected with SV40 tAg-defective genomes stimulates DNA replication [20]. Recently, tAg was shown to have a sig
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